While the etiology and mechanisms underpinning the pathogenesis of autism spectrum disorder (ASD) continue to be under investigation, identifying unique metabolomic patterns in children with ASD is one promising avenue. Re-examining the data collected from a nutritional supplementation study on a cohort of children with ASD, this work seeks to better elucidate the mechanisms behind how nutritional intervention impacts changes in recipients’ behavior and underlying metabolomics. Among biochemical measurements that were identified at baseline as being significant distinct between typically developing and ASD cohorts, 50% no longer significantly differed after intervention. Furthermore, among the correlational relationships observed, nutritional intervention was associated with a shift towards correlations between metabolites more like that of a comparable typically developing cohort.
Proceedings of the FOSBE 2022, Cambridge, Massachusetts, pp. 156-160 (2022)